Simple and efficient nickel-catalyzed cross-coupling reaction of alkynylalanes with benzylic and aryl bromides.
نویسندگان
چکیده
Highly efficient and simple coupling reactions of benzylic and aryl bromides with aluminium acetylide catalyzed by NiCl(2)(PPh(3))(2) are reported. The coupling reactions proceed at room temperature employing 4 mol% catalyst, affording coupling products in excellent yields of up to 95% in short reaction times. The system worked efficiently with aryl and heterocyclic bromides as well.
منابع مشابه
An efficient nickel-catalyzed alkenylation of functionalized benzylic halides with alkenylaluminum reagents.
Highly efficient and simple coupling reactions of benzylic bromides or chlorides with alkenylaluminum reagents catalyzed by NiCl(2)(PPh(3))(2) are reported. The coupling reactions proceed effectively at room temperature employing low loading of catalyst, 0.5 mol% for benzylic bromides having either electron-donating or -withdrawing substituents on the aromatic ring, affording coupling products ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 37 شماره
صفحات -
تاریخ انتشار 2011